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Preclinical study demonstrates noninvasive fluorescence detection of early breast cancer bone metastases using pH-activatable probes, highlighting superior sensitivity over X-rays.
) allowed the successful targeting and visualization of deep-seated bone metastases of breast cancer with a high tumor to normal contrast of 8/1, outperforming X-rays in early detection. This strategy may provide insights for designing high-brightness activatable NIR probes for detecting deep-seated tumors and metastases.
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Wu et al. (2021) studied this question.
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