Why the study?
Does the response to a cold pressor test reveal endothelial dysfunction in patients with impaired glucose tolerance and type 2 diabetes compared to healthy subjects?
Does the response to a cold pressor test reveal endothelial dysfunction in patients with impaired glucose tolerance and type 2 diabetes compared to healthy subjects?
Endothelial dysfunction is detectable in the preclinical stage of diabetes (impaired glucose tolerance) using a cold pressor test to assess microvascular tone.
May support cold pressor testing to detect preclinical endothelial dysfunction in impaired glucose tolerance; leaves open prospective validation before clinical adoption.
The objective of this study is to explore changes in microvascular tone during a contralateral cold pressor test and to compare the results obtained in healthy subjects and in patients with impaired glucose tolerance (IGT) and type 2 diabetes. Low-amplitude fluctuations of skin temperature in the appropriate frequency ranges were used as a characteristic for the mechanism for vascular tone regulation. In total, 13 adults with type 2 diabetes aged 40-67 years and 18 adults with IGT aged 31-60 years participated in this pilot study. The control group included 12 healthy men and women aged 39-60 years. The response to the cold pressor test in patients with type 2 diabetes and with IGT differs essentially from that of healthy subjects in the endothelial frequency range. Endothelial dysfunction occurs in the preclinical stage of diabetes and manifests, in particular, as a disturbance of the endothelial part of vascular tone regulation.
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Смирнова et al. (2013) studied this question.
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