Why the study?
Does lidocaine compared to procaine amide prevent circulatory depression while maintaining antiarrhythmic efficacy in patients undergoing cardiac operations?
Population
12 patients undergoing cardiac operations
Comparison
Lidocaine 1.0 to 2.0 mg/kg vs Procaine amide 2.0 or 4.0 mg/kg
Design
Cohort
Authors
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Should not yet change antiarrhythmic selection in cardiac surgery; leaves open need for randomized confirmation of hemodynamic differences.
Does lidocaine compared to procaine amide prevent circulatory depression while maintaining antiarrhythmic efficacy in patients undergoing cardiac operations?
Lidocaine is preferable to procaine amide for managing ventricular arrhythmias during cardiac surgery due to its lack of circulatory depression.
Harrison et al. (1963) studied this question.
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