Molecular Diseases of Hemoglobin. I. Introduction and Incidence

Article1 June 1957MOLECULAR DISEASES OF HEMOGLOBIN. I. INTRODUCTION AND INCIDENCETOM P. HAYNIE, M.D., HAROLD L. DOBSON, M.D., ROBERT A. HETTIG, M.D.TOM P. HAYNIE, M.D.Search for more papers by this author, HAROLD L. DOBSON, M.D.Search for more papers by this author, ROBERT A. HETTIG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-6-1031 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHISTORICALThe discovery by Pauling, Itano, Singer and Wells1 that normal and sickle cell hemoglobins have different electrophoretic mobilities provoked a great amount of thought and investigation concerning the molecular aberrations of hemoglobin. To the clinician as well as to the medical investigator, this discovery crystallized the concept that a molecular abnormality in a single substance might cause a sequence of events productive of serious disease states. For the clinical hematologist and the geneticist, the study of abnormal hemoglobins has provided a method of classifying inherited hemoglobin disorders which no other approach has equaled in simplicity and accuracy.Prior to...Bibliography1. PaulingItanoSingerWells LHASJIC: Sickle cell anemia, a molecular disease, Science 110: 543, 1949. CrossrefMedlineGoogle Scholar2. Itano HA: Human hemoglobin, Science 117: 89, 1953. CrossrefMedlineGoogle Scholar3. Pauling L: Abnormality of hemoglobin molecules in hereditary hemolytic anemias, Vol. 49, The Harvey Lectures, 216-241, 1953-4. MedlineGoogle Scholar4. Margolies MP: Sickle cell anemia; composite study and survey, Medicine 30: 357, 1951. CrossrefMedlineGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication November 30, 1956.From the Department of Internal Medicine, Baylor University College of Medicine, and Jefferson Davis Hospital, Houston, Texas.†Written to fulfill the requirements for the Senior Thesis in Internal Medicine.Requests for reprints should be addressed to Harold L. Dobson, M.D., Department of Medicine, Baylor University College of Medicine, Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDistributions of Genetic Markers in United States Populations: III. Serum Group Systems and Hemoglobin VariantsFrequency of Hemoglobinopathies in SarcoidosisSIGMUND R. GREENBERG, M.D., JEAN ATWATER, B.S., HAROLD L. ISRAEL, M.D., F.A.C.P.Studies into maternal influences on the well-being of the fetus and newbornPregnancy in sickle cell anemia, sickle cell-hemoglobin C disease, and variants thereofIncidence and significance of abnormal hemoglobinsA CRITICAL REVIEW OF HUMAN HAEMOGLOBIN VARIANTS: PART II: INDIVIDUAL HAEMOGLOBINSSICKLE CELL-HEMOGLOBIN D DISEASE*ERNEST W. SMITH, C. LOCKARD CONLEY, F.A.C.P. 1 June 1957Volume 46, Issue 6Page: 1031-1038KeywordsAnemiaGeneticsHematology and oncologyHemoglobinHospital medicineSickle cell hemoglobinThalassemia ePublished: 1 December 2008 Issue Published: 1 June 1957 PDF downloadLoading ...