Remission of Tumor-Stage Mycosis Fungoides Following Intravenously Administered Acyclovir

MYCOSIS fungoides is a T-cell lymphoma that begins in the skin, frequently involves internal organs, and is usually fatal. Chronic dermatitis may be the initial manifestation of the disease, with plaques, tumors, and ulcerations developing later. Altered immunity is common in the late stages of the disease, and death is frequently caused by infection. After the formation of cutaneous tumors, the median survival time is less than three years despite various forms of treatment.¹The cause of mycosis fungoides is not known, but chronic stimulation of the immune system by viral antigens has been postulated to be important in the pathogenesis of lymphomas, including mycosis fungoides.² We report a case of complete clearing of extensive ulcerated tumors in a patient with mycosis fungoides following therapy with intravenously (IV) administered acyclovir. REPORT OF A CASE A 58-year-old woman with a seven-year history of scaly papules and plaques on the