Cytomegalic Inclusion Disease in Patients with Acute Leukemia

Article1 May 1965Cytomegalic Inclusion Disease in Patients with Acute LeukemiaGERALD P. BODEY, M.D., PAUL T. WERTLAKE, M.D., GEORGE DOUGLAS, M.D., ROBERT H. LEVIN, M.D.GERALD P. BODEY, M.D.Search for more papers by this author, PAUL T. WERTLAKE, M.D.Search for more papers by this author, GEORGE DOUGLAS, M.D.Search for more papers by this author, ROBERT H. LEVIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-899 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCytomegalic inclusion disease (CID), the result of infection with the salivary gland virus (SGV), has been reported frequently as a cause of morbidity and mortality in newborns and infants. However, less than 60 infections have been reported in adults, where it usually occurs as a complication of chronic, debilitating diseases, especially hematologic malignancies (1-7). Since there is no pathognomonic constellation of signs and symptoms in the adult, CID is rarely diagnosed antemortem.Recently, the diagnosis of CID was established in 13 acute leukemia patients at the Clinical Center of the National Institutes of Health. Eleven of these patients died within...References1. WONGWARNER TWNE: Cytomegalic inclusion disease in adults. Arch. Path. (Chicago) 74: 403, 1962. MedlineGoogle Scholar2. LEVILLAINBAUFLEPAGEANTLENYS RGHGR: Cytoplasmic inclusion disease complicating the course of eosinophilic leukemia in a 75 year old man. Ann. Sci. Univ. Besancon 6: 187, 1962. Google Scholar3. PEACE RJ: Cytomegalic inclusion disease in adults. Amer. J. Med. 24: 48, 1958. CrossrefMedlineGoogle Scholar4. NELSONWYATT JSJP: Salivary gland virus disease. Medicine (Balt.) 38: 223, 1959. CrossrefMedlineGoogle Scholar5. GOTTMANNBEATTY AWEC: Cytomegalic inclusion disease in children with leukemia or lymphosarcoma. Amer. J. Dis. Child. 104: 180, 1962. MedlineGoogle Scholar6. DELVAUX TC: Viral lesions complicating lymphoma in an adult. Amer. J. Clin. Path. 28: 286, 1957. CrossrefMedlineGoogle Scholar7. ZUBRODROSENBERGSHUMANKNIGHTROWEEDGECOMBHILBISH CGLWRVWJRF: Unexplained death in a patient with leukemia: Clinical pathological conference at the National Institutes of Health. Ann. Intern. Med. 53: 1211, 1960. LinkGoogle Scholar8. SMITHVELLIOS MGF: Inclusion disease or generalized salivary gland virus infection. Arch. Path. (Chicago) 50: 862, 1950. MedlineGoogle Scholar9. WYATTSAXTONLEEPINKERTON JPJRSH: Generalized cytomegalic inclusion disease. J. Pediat. 36: 271, 1950. CrossrefMedlineGoogle Scholar10. FARBERWOLBACH SSB: Intranuclear and cytoplasmic inclusions ("Protozoa-like bodies") in the salivary glands and other organs of infants. Amer. J. Path. 8: 123, 1932. MedlineGoogle Scholar11. MEDERIS DN: Cytomegalic inclusion disease with an analysis of the clinical features based on the literature and six additional cases. Pediatrics 19: 467, 1957. MedlineGoogle Scholar12. WELLERHANSHAW THJB: Virologic and clinical observations on cytomegalic inclusion disease. New Eng. J. Med. 266: 1233, 1962. CrossrefMedlineGoogle Scholar13. LEVINEWARNERJOHNSON RSNECF: Cytomegalic inclusion disease in the gastrointestinal tract of adults. Ann. Surg. 159: 37, 1964. CrossrefMedlineGoogle Scholar14. WYATTSIMONTRUBELLEVANS JPTMLM: Cytomegalic inclusion pneumonitis in the adult. Amer. J. Clin. Path. 23: 353, 1953. CrossrefGoogle Scholar15. ROWEHARTLEYWATERMANTURNERHUEBUER WPJWSHCRJ: Cytopathogenic agent resembling human salivary gland virus recovered from tissue of human adenoids. Proc. Soc. Exp. Biol. Med. 92: 418, 1956. CrossrefMedlineGoogle Scholar16. KILBOURNE ED: Influence of cortisone on experimental viral infection. IV. Negation of interference as the mechnism by which cortisone induces increased virus yields. J. Exp. Med. 106: 863, 1957. CrossrefMedlineGoogle Scholar17. KILBOURNESMARTPOKORRNEY EDKMBA: Inhabition by cortisone of the synthesis and actions of interferon. Nature (London) 190: 650, 1961. CrossrefMedlineGoogle Scholar18. FISHERDAVIS ERE: Cytomegalic inclusion disease in the adult. New Eng. J. Med. 258: 1036, 1958. CrossrefMedlineGoogle Scholar19. LEVINLANDYFREI RHME: The effect of 6-mercaptopurine on immune response in man. New Eng. J. Med. In press. Google Scholar20. JANSSENMARSHALLGERONECHEVILL RJRGPJNS: The effects of 6-mercaptopurine on variola infections in Rhesus monkeys. I. The influence of the drug on the resistance and immunological response of the infected host. J. Infect. Dis. 111: 155, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GERALD P. BODEY, M.D.; PAUL T. WERTLAKE, M.D.; GEORGE DOUGLAS, M.D.; ROBERT H. LEVIN, M.D.Affiliations: Bethesda, MarylandFrom the Medicine Branch and Department of Pathological Anatomy, National Cancer Institute, National Institutes of Health, Bethesda, Md.Dr. Levin died on July 9, 1964.Requests for reprints should be addressed to Gerald P. Bodey, M.D., National Cancer Institute, National Institutes of Health, Building 10, Room 2B48, Bethesda, Md. 20014. 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HILL JR., M.D.Die Durchseuchung der Bevölkerung mit dem im Tierversuch kanzerogenen Adenovirus Typ 18Congenital and Acquired Cytomegalovirus InfectionRecovery of Cytomegalovirus from Adults with Neoplastic DiseaseCHARLES P. DUVALL, M.D., ALBERT R. CASAZZA, M.D., PHILIP M. GRIMLEY, M.D., PAUL P. CARBONE, M.D., WALLACE P. ROWE, M.D. 1 May 1965Volume 62, Issue 5Page: 899-906KeywordsHematologic malignanciesHuman cytomegalovirusInfantsInfectious diseasesMorbidityMortalitySigns and symptoms ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...