Why the study?
Microvascular injury occurs in up to 50% of STEMI patients without targeted therapies, and inflammation may deleteriously affect the microcirculation.
Does prehospital pulse-dose glucocorticoid improve index of microvascular resistance in patients with STEMI transferred for primary PCI?
Population
295 STEMI patients transferred for primary PCI assessed with coronary physiology
Comparison
Prehospital methylprednisolone 250 mg vs placebo
Design
Prespecified sub-study of a 1:1 randomized, blinded, placebo-controlled clinical trial
Follow-up
24 hours
Authors
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Glucocorticoid did not improve IMR despite anti-inflammatory effects; leaves open whether targeted inflammation reduction can protect microcirculation in STEMI.
Does prehospital pulse-dose glucocorticoid improve index of microvascular resistance in patients with STEMI transferred for primary PCI?
Prehospital pulse-dose glucocorticoid in STEMI patients reduces inflammation at 24 hours but does not improve microvascular resistance immediately after primary PCI.
Lønborg et al. (2025) studied this question.