What does this research mean for the field?

Left ventricular dyssynchrony assessed by phase analysis of gated myocardial perfusion SPECT correlates strongly with tissue Doppler imaging, particularly using histogram bandwidth and phase standard deviation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the assessment of left ventricular dyssynchrony using phase analysis of gated myocardial perfusion SPECT against tissue Doppler imaging.

August 19, 2026Journal of the American College of CardiologyOpen Access

Phase Analysis of Gated Myocardial Perfusion Single-Photon Emission Computed Tomography Compared With Tissue Doppler Imaging for the Assessment of Left Ventricular Dyssynchrony

Q: What are the key findings of this study?

Left ventricular dyssynchrony assessed by GMPS correlated well with TDI, particularly for histogram bandwidth (r=0.89, p<0.0001) and phase SD (r=0.80, p<0.0001).

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Heart failure with depressed LV function and wide QRS complex (n=75). Intervention: Gated myocardial perfusion single-photon emission computed tomography (GMPS) vs. Tissue Doppler imaging (TDI). Primary outcome: Correlation of LV dyssynchrony parameters between GMPS and TDI (r = 0.89, p=<0.0001).

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Key result

GMPS correlates strongly with TDI for assessing LV dyssynchrony, peaking at ~0.89 for histogram bandwidth.

r = 0.89
P<0.0001
n=75

Why the study?

LV dyssynchrony predicts response to CRT and is predominantly assessed by TDI, but whether GMPS phase analysis compares well to TDI for assessing dyssynchrony was unclear.

Does gated myocardial perfusion SPECT correlate with tissue Doppler imaging for the assessment of left ventricular dyssynchrony in patients with heart failure?

Key Points

To compare the assessment of left ventricular dyssynchrony using phase analysis of gated myocardial perfusion SPECT against tissue Doppler imaging.
Evaluated 75 patients with heart failure, depressed left ventricular function, and wide QRS complex being screened for cardiac resynchronization therapy.
Performed gated myocardial perfusion SPECT phase analysis (assessing histogram bandwidth, phase SD, skewness, and kurtosis) alongside 2D echocardiography with tissue Doppler imaging.
Analyzed the relationship between SPECT-derived phase parameters and tissue Doppler imaging dyssynchrony using Pearson's correlation.
Histogram bandwidth and phase standard deviation from SPECT correlated strongly with tissue Doppler imaging dyssynchrony (r = 0.89, p < 0.0001 and r = 0.80, p < 0.0001, respectively).
Histogram skewness and kurtosis showed moderate inverse correlations with tissue Doppler imaging dyssynchrony (r = -0.52, p < 0.0001 and r = -0.45, p < 0.0001, respectively).

Study Design

Type

Cross-Sectional (n=75)

Structured PICO

Does gated myocardial perfusion SPECT correlate with tissue Doppler imaging for the assessment of left ventricular dyssynchrony in patients with heart failure?

Population

75 patients with heart failure, depressed LV function, and wide QRS complex undergoing clinical screening for eligibility for cardiac resynchronization therapy.

Exposure

Gated myocardial perfusion single-photon emission computed tomography (SPECT) (GMPS) with phase analysis

Comparator

Tissue Doppler imaging (TDI) with 2-dimensional echocardiography

Outcome

Correlation of left ventricular dyssynchrony parameters (histogram bandwidth, phase SD, histogram skewness, and histogram kurtosis) between GMPS and TDIsurrogate

Main Result

Effect estimate: r = 0.89

p-value: p=<0.0001

Limitations

Outcome studies after CRT are needed to further validate the use of GMPS for assessment of LV dyssynchrony.
Outcome studies after CRT are needed to further validate the use of GMPS for assessment of LV dyssynchrony

Discussion

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Implication

Gated myocardial perfusion SPECT phase analysis, specifically histogram bandwidth and phase SD, correlates well with tissue Doppler imaging for assessing left ventricular dyssynchrony in heart failure patients.

Cite This Study

Henneman et al. (2007) conducted a cross-sectional in Heart failure with depressed LV function and wide QRS complex (n=75). Gated myocardial perfusion single-photon emission computed tomography (GMPS) vs. Tissue Doppler imaging (TDI) was evaluated on Correlation of LV dyssynchrony parameters between GMPS and TDI (r = 0.89, p=<0.0001). Left ventricular dyssynchrony assessed by GMPS correlated well with TDI, particularly for histogram bandwidth (r=0.89, p<0.0001) and phase SD (r=0.80, p<0.0001).

synapsesocial.com/papers/6a85ebafb4e7c7796c8c7bfe https://doi.org/10.1016/j.jacc.2007.01.063

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Phase Analysis of Gated Myocardial Perfusion Single-Photon Emission Computed Tomography Compared With Tissue Doppler Imaging for the Assessment of Left Ventricular Dyssynchrony

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Phase Analysis of Gated Myocardial Perfusion Single-Photon Emission Computed Tomography Compared With Tissue Doppler Imaging for the Assessment of Left Ventricular Dyssynchrony

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider