Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant

Curcumin (CMN) has been well studied due to its economic and medical importance. Traditional Egyptian Medicine claims the use of its powder against biliary disorders, anorexia, coryza, cough, diabetic wounds, hepatic disorder, rheumatism and sinusitis. The current study was designed to examine the possible beneficial effect of CMN in preventing the acute renal failure and related oxidative stress caused by chronic administration of cyclosporine (CsA) in rats. The study included two experiments, the first one was carried out to follow up the changes that could occur in kidney function as a result of cyclosporine (CsA) administration. Cyclosporine administration exerted significant (P< 0.01) elevation of serum urea, creatinine, potassium (K), parathormone (PTH), malondialdehyde (MDA) and asymmetrical dimethylarginine (ADMA). Meanwhile, cyclosporine treatment exerted significant (P< 0.01) decline in the level of serum sodium (Na) and total nitric oxide (NO), the content of kidney reduced glutathione (GSH) and the activities of glutathione peroxidase (Gpx), catalase (CAT) and superoxide dismutase (SOD) as compared with their corresponding normal rats. In the second experiment, the nephritic rats were treated with curcumin and remarkable corrections were occurred in all previous parameters. Thus, the current investigation was designed to examine the possible beneficial effect of CMN in preventing the renal failure and related oxidative stress caused by administration of CsA in rats.