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August 12, 2022Journal of Alzheimer s DiseaseOpen Access

Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG): A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS1

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Why the study?

Ethnic differences in cognitive decline have been reported, but whether they can be explained by differences in systolic blood pressure remains uncertain.

Does cumulative mean SBP explain differences in cognitive decline between Hispanic and White individuals?

Population

24,570 Hispanic and White participants free of stroke and dementia from six cohorts

Comparison

Cumulative mean SBP levels in Hispanic vs White individuals

Design

Pooled cohort study of individual participant data

Follow-up

Median 7.7 (Q1-Q3, 5.2-20.1) years

Authors

DLDeborah A. LevineAGAlden L. GrossEBEmily M. Briceño

Discussion

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Overview

SBP control unlikely to close ethnic cognitive gaps; hypothesis-generating for other disparity drivers in diverse cohorts.

Structured PICO

Does cumulative mean SBP explain differences in cognitive decline between Hispanic and White individuals?

P
Population
24,570 participants free of stroke and dementia from six pooled cohorts (1971-2017), including 2,475 Hispanic individuals (median age 67 years, 40.8% men) and 22,095 White individuals (median age 60 years, 47.3% men).
I
Intervention
Cumulative mean systolic blood pressure (SBP) levels
C
Comparator
Hispanic vs White individuals
O
Outcome
Changes in global cognition (GC)surrogate

Cumulative mean systolic blood pressure is associated with cognitive decline but does not explain the differences in cognitive decline trajectories between Hispanic and White individuals.

Cite This Study

Levine et al. (2022) studied this question.

synapsesocial.com/papers/6a8646e479a480030073a1ddhttps://doi.org/10.3233/jad-220366
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