Development of human intestinal and gastric enzymes

In humans as opposed to rodents development of the gastrointestinal tract is much less coordinated with functional changes occurring at different times during the fetal period. This article reviews developmental patterns of intestinal brush border enzymes, lysosomal enzymes, peroxisomal enzymes and de novo synthesis of intestinal lipoproteins. It also describes the developmental patterns of gastric lipase and pepsin during early fetal life. Data are presented on the most recent observations related to the regulatory mechanisms in the development of human intestinal brush border hydrolases. A clearer understanding of the ontogeny and of the regulatory mechanism of the functional development of the gastrointestinal tract will enable researchers and clinicians to improve nutritional support in a fashion appropriate for the digestive and metabolic capabilities of an infant at any developmental stage.