A corrected, open-source SIMULINK implementation of Guyton's circulatory dynamics model accurately simulates physiological responses to various pathological conditions.
Validates open-source Guyton's model for hemodynamic simulation; leaves open any clinical role pending prospective validation.
We present the current state of complex circulatory dynamics model development based on Guyton's famous diagram. The aim is to provide an open-source model that will allow the simulation of a number of pathological conditions on a virtual patient including cardiac, respiratory, and kidney failure. The model will also simulate the therapeutic influence of various drugs, infusions of electrolytes, blood transfusion, etc. As a current result of implementation, we describe a core model of human physiology targeting the systemic circulation, arterial pressure and body fluid regulation, including short- and long-term regulations. The model can be used for educational purposes and general reflection on physiological regulation in pathogenesis of various diseases.
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Kofránek et al. (2010) studied this question.
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