Is it time to revisit the classification guidelines for primary progressive aphasia?

Hair-splitting details of syndromic classification can hardly be expected to generate much excitement. As in all areas of science, however, sound nosology and uniform nomenclature are important for progress in neurology. This is particularly true for the neurodegenerative syndromes, including primary progressive aphasia (PPA), where heterogeneity of phenotype and cellular pathology has defied attempts to find coherent clinicopathologic correlations.