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January 1, 1978Pacing and Clinical Electrophysiology

Clinical Value of Tests of Sino‐Atrial Function*

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Why the study?

Do tests of sino-atrial function predict the need for permanent pacemaker implantation in patients with suspected sinus node disease?

Population

36 patients

Design

Cohort

Authors

TET R EvansUniversity of OxfordECE. A. CallowhillHammersmith HospitalDKD M KriklerGuy's Hospital

Discussion

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Overview

Corrected sinus node recovery time may aid prediction in suspected sinus node disease; leaves open its role in guiding implantation without prospective validation.

Key Points

  • To evaluate the clinical utility of sinus node recovery times and premature atrial stimulation testing in diagnosing sinus node disease and predicting pacemaker requirement.
  • Evaluated 36 patients categorized into gross sinus node disease (N=7), possible sinus node disease (N=25), and controls without clinical sinus node disease (N=4).
  • Performed electrophysiological assessments including sinus node recovery times (and corrected sinus node recovery time) and the premature atrial stimulus test.
  • Corrected sinus node recovery time proved most predictive for identifying patients requiring and benefiting from permanent pacemaker implantation, despite one false negative and two asymptomatic abnormal findings.
  • The premature atrial stimulus test lacked practical diagnostic value in severe disease, and data could only be analyzed in 13 of 25 suspected cases due to excessive curve scatter caused by arrhythmias.
  • Overdrive sinus node suppression was identified as the only useful invasive study when regular sinus rhythm is absent on baseline electrocardiography.

Structured PICO

Do tests of sino-atrial function predict the need for permanent pacemaker implantation in patients with suspected sinus node disease?

P
Population
36 patients (7 with gross sinus node disease, 25 with possible sinus node disease, and 4 with no clinical evidence of sinus node disease)
I
Intervention
Tests of sino-atrial function (sinus node recovery times and premature atrial stimulus test)
O
Outcome
Prediction of need and benefit from permanent pacemaker implantation

Corrected sinus node recovery time is a valuable predictor for pacemaker implantation in suspected sinus node disease, whereas premature atrial stimulation has limited practical utility.

Cite This Study

Evans et al. (1978) studied this question.

synapsesocial.com/papers/6a8654305dc285e07e73a3cahttps://doi.org/10.1111/j.1540-8159.1978.tb03434.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Significance of the Sinus-Node Recovery Time1972 · 461 citations
  2. 2Measurement of Sinoatrial Conduction Time by Premature Atrial Stimulation in the Rabbit1974 · 75 citations
  3. 3Premature Atrial Stimulation as a Key to the Understanding of Sinoatrial Conduction in Man1973 · 453 citations
  4. 4Sinoatrial-Node Entrance Block1971 · 101 citations
  5. 5Evaluation of Sino-atrial Node Function in Man by Overdrive Suppression1971 · 408 citations