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August 1, 2006International Journal of Geriatric Psychiatry

Orthostatic hypotension in Parkinson's disease: association with cognitive decline?

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Why the study?

Is orthostatic hypotension associated with cognitive decline in patients with Parkinson's disease?

Population

175 Parkinson's disease (PD) patients

Comparison

Orthostatic hypotension vs PD patients without orthostatic hypotension

Design

Cross-sectional

Authors

LALiesl M. AllcockRKRose Anne KennyUMUrs P. Mosimann

Discussion

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Member takes

Overview

OH may flag PD patients for cognitive monitoring; hypothesis-generating, needs longitudinal trials before practice change.

Structured PICO

Is orthostatic hypotension associated with cognitive decline in patients with Parkinson's disease?

P
Population
175 Parkinson's disease (PD) patients
I
Intervention
Orthostatic hypotension (OH) (systolic BP drop of >=20 mmHg or a systolic pressure of <90 mm Hg after standing)
C
Comparator
PD patients without orthostatic hypotension
O
Outcome
Cognitive performance assessed using MMSE extended by computerized cognitive tests (reaction time, sustained attention, working memory, episodic verbal and visual memory)surrogate

Orthostatic hypotension in Parkinson's disease is associated with worse performance in sustained attention and visual episodic memory, suggesting it may be a marker for cognitive decline.

Cite This Study

Allcock et al. (2006) studied this question.

synapsesocial.com/papers/6a8655dc85b962098c2fd556https://doi.org/10.1002/gps.1562
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