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The author recommends that, contrary to currently accepted protocol, patients undergo skin testing before receiving injectable hyaluronic acid (HA) gel fillers. The risk of hypersensitivity to HA gel fillers, although low compared with bovine collagen, is a factor to consider. As larger volumes of fillers are injected, more extensive and vigorous reactions may be seen.
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Karyn L. Grossman (2005) studied this question.
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