For metabolic studies the fragmentation of a novel endothelin receptor antagonist, Bosentan, was investigated using ionspray tandem mass spectrometry. Bosentan belongs to the sulphonamide class and a complicated and unexpected fragmentation at low energy, involving a radical fragmentation of an even-electron ion at the sulphonamide bond, is reported.
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Hopfgartner et al. (1996) studied this question.