Population
Rats made hypertensive by unilateral nephrectomy/renal wrap for 4 weeks and normotensive rats.
Comparison
Unilateral nephrectomy/renal wrap to induce… vs Normotensive control rats
Design
Preclinical
Follow-up
4 weeks
Authors
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May link NTS current changes to baroreflex impairment in hypertension; hypothesis-generating and requires confirmation in higher models.
Hypertension of 4-week duration reduces transient outward potassium currents in NTS neurons, which may contribute to altered baroreflex function.
Belugin et al. (2005) studied this question.
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