Why the study?
Does preoperative oral application of lactobin reduce endotoxin translocation and mediator release in patients undergoing abdominal surgery?
Population
40 patients treated by partial (n = 4) or total gastrectomy (n = 8) or pancreatic resection (n = 28)
Comparison
Oral application of a bovine milk preparation… vs Placebo for 3 days pre-operatively
Design
RCT, randomly treated, placebo-controlled
Follow-up
daily evaluation post-operatively
Authors
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Supports preoperative lactobin to stabilize gut barrier in abdominal surgery; extends probiotic evidence in perioperative care.
Does preoperative oral application of lactobin reduce endotoxin translocation and mediator release in patients undergoing abdominal surgery?
Prophylactic oral application of lactobin reduces perioperative endotoxemia and prevents reduction of ENC, suggesting a stabilization of gut barrier during abdominal surgery.
lke et al. (2002) studied this question.
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