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The ‘ideal’ plasma substitute for volume replacement remains a matter of dispute. Merits and demerits of colloids versus crystalloids for volume replacement have been discussed very emotionally. Are we any wiser concerning the crystalloid/colloid problem? Recently published meta-analyses or evidence-based medicine analyses appear to be less helpful to solve this problem. Conflicting results from different studies are most likely as a result of variations in clinical protocols, selection of patients, criteria for blood or volume administration. With their conflicting results more questions arise than answers are given.
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Joachim Boldt (2010) studied this question.
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