This basic science study provides new mechanistic insights into how cardiac t-tubular membranes respond to osmotic forces, demonstrating that sealing is initiated by detachment from the cytoskeleton.
Preclinical mechanism of t-tubule sealing warrants no clinical change; leaves open in vivo relevance to human cardiomyopathy.
This study provides new insights into how t-tubular membranes respond to osmotic forces. In particular, the data show that osmotically induced sealing of cardiac t tubules is a threshold phenomenon initiated by detachment of t-tubular membrane from the underlying cytoskeleton. The findings are consistent with the hypothesis that final sealing of t tubules is driven by negative hydrostatic intracellular pressure coincident with cell shrinking.
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Uchida et al. (2020) studied this question.
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