Cloning, Functional Analysis, and Breeding Application of the Powdery Mildew Resistance Gene MlWE74 in Wheat

The MlWE74  gene, a novel powdery mildew resistance gene, has garnered widespread attention for its potential to enhance disease resistance in wheat. This study provides a comprehensive summary of the positional cloning, functional analysis, and breeding application of the wheat powdery mildew resistance gene MlWE74 . A systematic analysis of the cloning strategy, functional mechanisms, and its application in molecular breeding was conducted, evaluating its contributions to disease resistance improvement and its practical value in modern wheat breeding. The findings reveal that the MlWE74  gene holds significant potential for use in wheat disease resistance breeding. Its functional analysis and breeding applications will further advance the development of resistant wheat varieties. Future research should focus on in-depth studies of the MlWE74  gene, combining gene editing and multi-gene resistance strategies to enhance its breeding efficiency. The successful cloning and functional analysis of the MlWE74  gene offer new perspectives and tools for the development of powdery mildew-resistant wheat varieties. With the advancement of genome selection, marker-assisted breeding, and gene editing technologies, the application of MlWE74  is expected to greatly improve disease resistance in wheat varieties, contributing to global food security.