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May guide chemical biology strategies in neurobiology and virology; leaves open clinical translation of dsRNA-binding enzyme modulation.
Duplex RNA-binding proteins are key players in a number of fields, including neurobiology, virology, and development. In this minireview, five human enzymes are discussed that bind duplex RNA through double-stranded RNA-binding motifs, including RNA-editing adenosine deaminases. Also highlighted are opportunities for advancing our understanding of these fascinating enzymes by chemical biology.
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Peter A. Beal (2005) studied this question.
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