We treated three patients with Bowen's disease for 3 months with local hyperthermia with chemical pocket warmers. The clinical courses were marked by the following changes: by the second or third week of treatment, the nodular lesions had become flattened and the erythematous and infiltrated lesions showed a considerable reduction, and by weeks 5 and 6 the lesions had become almost entirely pigmented. Post-treatment histopathological examination revealed several tumour cells remaining in case 1, and an absence of tumour cells in case 2; but in case 3 no pathological tests were possible. The results of the therapy were not perfect, but the technique is extremely promising for the treatment of Bowen's disease.
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Hiruma et al. (1994) studied this question.
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