Characterization of vilyuisk virus as a picornavirus

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Structured PICO

Population

V-1 strain of Vilyuisk virus, isolated from the cerebrospinal fluid of a chronic case of encephalomyelitis in Siberia and passaged 41 times in mice

Intervention

Physicochemical characterization and serological relationship testing using ELISA

Comparator

Theiler's murine encephalomyelitis virus (TMEV) and encephalomyocarditis (EMC) virus

Outcome

Virion characteristics (size, symmetry, buoyant density, sedimentation coefficient, capsid polypeptide profile) and antigenic relatedness

Vilyuisk virus is characterized as a picornavirus, antigenically related to TMEV but not EMC virus.

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Refines picornavirus taxonomy in encephalomyelitis models; leaves open its human pathogenicity.

Lipton et al. (1983) studied this question.

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