Inhibition of glycolysis in rat skeletal muscle by malonate

Fawaz, Although 0 03M-malonate ;almost completely inhibited the Krebs cycle in -pigeon-breast or sheep-heart mince, it had no deleterious effect on the performance of the heart; however, a substantial amount of succinate accumulated in the cardiac tissue. When the concentration of malonate was raised to 0-06M, rapid failure ensued, accompanied by a decreased heart rate and