Genetics of somatic mammalian cells. XV. Evidence for linkage between human genes for lactic dehydrogenase B and serine hydroxymethylase

Chinese hamster ovary cells with a deficiency in Serine Hydroxymethylase which produces a specific glycine auxotrophy (gly − A) were fused with human cells from a variety of sources and the resulting hybrids analyzed for human gene linkage. Of 102 hybrid clones examined 65 possessed both glyA and lactic dehydrogenase B markers, 35 possessed neither marker. Two clones were found with altered glycine responses which were not linked to LDH‐B. The data indicate linkage between genes responsible for serine hydroxymethylase activity and lactic dehydrogenase B. Evidence for absence of linkage between these and a variety of other genes is also presented.