Why the study?
The study was conducted to describe the genetic diversity of enteroviruses causing HFMD and herpangina, especially coxsackievirus-A6, in pediatric primary care patients during the 2017–2018 season.
CV-A6 was the predominant enterovirus causing atypical HFMD in this pediatric cohort, with evidence of genetic recombination.
Supports EV surveillance in pediatric primary care; leaves open recombination effects on clinical severity.
Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017–2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.
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Andrés et al. (2019) studied this question.
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