Why the study?
Statins possess pleiotropic bioactivities through regulating cell adhesion molecules, prompting an overview of their regulatory effects across different diseases and potential roles in orthopedic disease.
Do statins exert therapeutic effects on inflammatory diseases through the regulation of cell adhesion molecules?
Do statins exert therapeutic effects on inflammatory diseases through the regulation of cell adhesion molecules?
Statins exhibit pleiotropic anti-inflammatory effects by regulating cell adhesion molecules, suggesting potential therapeutic applications beyond lipid lowering.
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Statins' pleiotropic effects may influence stem cell function; leaves open therapeutic applications in cardiovascular regeneration.
Simvastatin, lovastatin, rosuvastatin, pravastatin and cerivastatin belong to the statin family, which are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A. As the rate-limiting enzyme in the pathway of cholesterol metabolism, statins are classically prescribed to patients as lipidlowering agents. However, statins also possess several extra bioactivities, including anti-inflammatory, antiviral and anti-tumor. Interestingly, the most essential mechanism of these activities is that statins could regulate the expression of cell adhesion molecules (CAMs), especially, targeting lymphocytes function-associated molecules (LFA)-1, macrophage (Mac)-1 and intercellular adhesion molecules (ICAM)-1. Therefore, in this paper, we discussed the regulatory effect of statins on CAMs among different diseases. In addition, we provided speculation for the role of statins in treating orthopedic disease.
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Meng et al. (2020) studied this question.
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