What is the clinical evidence from this study?

Study design: RCT. Population: Aortic valve calcification (n=365). Intervention: MK-7 plus vitamin D vs. Placebo. Primary outcome: Change in AVC score (MD 17, 95% CI -86 to 53, p=0.64).

What question did this study set out to answer?

To evaluate whether daily supplementation with vitamin K2 (menaquinone-7) plus vitamin D slows the progression of aortic valve calcification in men with existing calcification.

August 20, 2026CirculationOpen Access

Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial

Q: What does this research mean for the field?

Daily supplementation with vitamin K2 (MK-7) plus vitamin D for 24 months does not significantly slow the progression of aortic valve calcification in elderly men. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

MK-7 plus vitamin D fails to slow aortic valve calcification progression vs. placebo.

MD 17
95% CI -86 to 53
P=0.64
n=365

Why the study?

Does daily treatment with 720 µg menaquinone-7 plus 25 µg vitamin D reduce the progression of aortic valve calcification in men with a baseline AVC score >300 AU?

Population

365 men from the community with an aortic valve calcification score >300 arbitrary units on cardiac…

Comparison

Daily treatment with tablet 720 µg menaquinone-7… vs Matching placebo for 24 months.

Design

RCT, randomized, double-blind

Follow-up

24 months

Discussion

Member takes

Implication

Daily supplementation with vitamin K2 (MK-7) and vitamin D for 2 years does not slow the progression of aortic valve calcification in elderly men.

Key Points

To evaluate whether daily supplementation with vitamin K2 (menaquinone-7) plus vitamin D slows the progression of aortic valve calcification in men with existing calcification.
Randomized, double-blind, multicenter trial (NCT03243890) conducted from February 2018 to March 2019.
Included 365 men (mean age 71.0 ± 4.4 years) with an aortic valve calcification (AVC) score >300 arbitrary units (AU) on noncontrast cardiac CT.
Participants received daily oral tablets of 720 µg MK-7 plus 25 µg vitamin D or matching placebo for 24 months.
The mean increase in AVC score was 275 AU (95% CI, 225–326 AU) in the intervention group versus 292 AU (95% CI, 246–338 AU) in the placebo group, with a nonsignificant mean difference in progression of 17 AU (95% CI, –86 to 53 AU; P=0.64).
No significant differences occurred in aortic valve area change (0.02 cm², 95% CI, –0.09 to 0.12 cm²; P=0.78), peak aortic jet velocity change (0.04 m/s, 95% CI, –0.11 to 0.02 m/s; P=0.21), or vascular calcification scores.
MK-7 plus vitamin D significantly decreased inactive dephosphorylated-undercarboxylated matrix Gla-protein levels (–212 pmol/L vs 45 pmol/L; P<0.001), while heart valve surgery, all-cause death (1 vs 4 patients; P=0.37), and cardiovascular events (10 vs 10 patients; P=0.99) did not differ.

Study Design

Type

RCT (n=365)

Blinding

Double-blind

Randomization

randomized

Multicenter

Yes

Structured PICO

Does daily treatment with 720 µg menaquinone-7 plus 25 µg vitamin D reduce the progression of aortic valve calcification in men with a baseline AVC score >300 AU?

Population

365 men with an aortic valve calcification score >300 AU, randomized to MK-7 plus vitamin D or placebo for 24 months.

Intervention

Daily treatment with tablet 720 µg menaquinone-7 (MK-7) plus 25 µg vitamin D for 24 months.

Comparator

Matching placebo for 24 months.

Outcome

Change in aortic valve calcification (AVC) score at 24 months.surrogate

Main Result

Mean Difference: 17 (95% CI -86–53)

Absolute Event Rate: 275% vs 292%

p-value: p=0.64

Daily supplementation with vitamin K2 (MK-7) and vitamin D for 2 years does not slow the progression of aortic valve calcification in elderly men.

Cite This Study

A 2022 study conducted an RCT in Aortic valve calcification (n=365). MK-7 plus vitamin D vs. Placebo was evaluated on Change in AVC score (MD 17, 95% CI -86 to 53, p=0.64). Daily supplementation with MK-7 plus vitamin D for 24 months did not significantly influence aortic valve calcification progression compared with placebo (mean difference 17 AU; P=0.64).

synapsesocial.com/papers/6a867228c83e1b491ea47322 https://doi.org/10.1161/circulationaha.121.057008

View Full Paper

Ask AI

Bookmark

Implication

Daily supplementation with vitamin K2 (MK-7) and vitamin D for 2 years does not slow the progression of aortic valve calcification in elderly men.

Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider