Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted. Examples of how solid-state analysis can be used to aid interpretation of dissolution results are also reviewed. We suggest the term physico-relevant dissolution testing to describe the combination of dissolution testing with solid-state analysis.
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Aaltonen et al. (2009) studied this question.
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