Mechanism and Regulation of Yeast RNA Polymerase II Transcription

The mRNA synthetic machinery of eukaryotes comprises general and gene-specific components. The general components, which include RNA polymerase II andgeneral transcription factors (GTFs), recognize and initiate transcription of a core, or minimal promoter, usuallyconsisting of a TATA box and transcription start site. Thegene-specific components include activator and repressorproteins, which interact with DNA elements termed enhancers and operators, respectively. Research summarized here is directed toward the mechanisms of bothtranscription initiation and its regulation...