Acromegaly and Pituitary Carcinoma

Letters15 December 1992Acromegaly and Pituitary CarcinomaShunichi Yamashita, MD, Motomori Izumi, MD, Shigenobu Nagataki, MDShunichi Yamashita, MD, Motomori Izumi, MD, Shigenobu Nagataki, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-12-1057 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Growth hormone (GH)-secreting adenocarcinoma with clear evidence of distant metastasis has been unequivocally documented in only five patients (1, 2).We report the case of an acromegalic patient with pituitary adenocarcinoma and elevated levels of circulating GH (80 μg/L) and insulin-like growth factor (IGF)-I (10 U/mL) as well as spinal cord metastasis.A 35-year-old Japanese woman was referred for further management of a previously diagnosed pituitary adenoma. She had been treated surgically at 19 and 31 years of age and with radiation at 33 and 34 years of age. Previous computed tomography showed a pituitary tumor, histologically...References1. MountcastleRoofMayfield RBR. Case report: pituitary adenocarcinoma in an acromegalic patient: response to bromocriptine and pituitary testing: a review of the literature on 36 cases of pituitary carcinoma. Am J Med Sci. 1989;298:109-18. CrossrefMedlineGoogle Scholar2. Melmed S. Acromegaly. N Engl J Med. 1990;322:966-77. CrossrefMedlineGoogle Scholar3. WaltzBrownell TB. Sarcoma: possible late result of effective radiation therapy for pituitary adenoma: report of two cases. J Neurosurg. 1966;24:901-7. CrossrefMedlineGoogle Scholar4. LambertsZweensVerschoorDel Pozo SMLE. A comparison among the growth hormone-lowering effects in acromegaly of the somatostatin analogue SMS 201-995, bromocriptine, and the combination of both drugs. J Clin Endocrinol Metab. 1986;63:16-9. CrossrefMedlineGoogle Scholar5. ChiodiniCozziDallabonzana PRD. Medical treatment of acromegaly with SMS 201-995, a somatostatin analog: a comparison with bromocriptine. J Clin Endocrinol Med. 1987;64:447-54. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nagasaki University School of Medicine Nagasaki 852 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGrowth hormone secreting pituitary carcinomas: Case report and review of literatureCorticotrophic pituitary carcinoma with cervical metastases: case series and literature reviewCytomorphology of metastatic pituitary carcinoma to the boneThe Role of Temozolomide in the Treatment of a Patient With a Pure Silent Pituitary Somatotroph CarcinomaMetastatic pituitary carcinoma in a patient with acromegaly: a case reportCorticotroph carcinoma of the pituitary: a clinicopathological studyProlactin-secreting pituitary carcinoma with implants in the cheek pouch and metastases to the ovaries. A case report and literature reviewClinical features and differential diagnosis of pituitary tumours with emphasis on acromegalyExpression of parathyroid hormone related peptide in human pituitary tumours. 15 December 1992Volume 117, Issue 12Page: 1057-1058KeywordsAcromegalyAdenocarcinomaComputed axial tomographyGrowth hormoneInsulin-like growth factorsPituitary tumorsSpinal cord Issue Published: 15 December 1992 PDF downloadLoading ...