Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics

CLINICAL QUESTION: In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? BOTTOM LINE: Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low-quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.