Axial ligation of the heme moiety by a proximal imidazole group is observed in a novel cytochrome c oxidase (CcO) active-site model 1 in which the copper ion is bound to a N-(2-hydroxyphenyl)imidazole moiety. Spectroscopic observations of 1 suggest the unique transformation of an initial heme–μ-peroxo–CuII species into a heme–superoxide/CuI intermediate in the course of the CcO oxygenation reaction at low temperature.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: