Ceramide, the product of sphingomyelin hydrolysis by neutral pH-optimum and magnesium-dependent sphingomyelinase (N-SMase), has been reported to increase in response to several inflammatory stimuli, including TNFa and IL-l/J and to play an important role in such stimulimediated physiological and pathological processes1~9). Intervention of the ceramide production, therefore, might
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Tanaka et al. (1999) studied this question.
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