A novel and simple but practical method for the preparation of modified poly(ether sulfone) (PES) membranes was provided by the in situ crosslinked copolymerization of sulfobetaine methacrylate (SBMA) and sodium p ‐styrene sulfonate (NaSS) in PES solution followed by a phase‐separation technique. Then, semi‐interpenetrating network membranes modified by the crosslinked copolymers of poly(sulfobetaine methacrylate‐ co ‐sodium p ‐styrene sulfonate) [P(SBMA‐ co ‐NaSS)] were prepared. The SBMA‐containing copolymer‐modified membranes showed improved protein antifouling properties with flux recovery ratios above 90%. Furthermore, the anticoagulant properties of the NaSS‐containing copolymer‐modified membranes were obviously enhanced; their activated partial thromboplastin time could be prolonged to about 115 s. Thus, the P(SBMA‐ co ‐NaSS) zwitterionic copolymer‐modified membranes showed improved antifouling properties and blood compatibility and will provide wide choices for their specific applications.
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Wang et al. (2014) studied this question.
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