SUMMARY 3‐ and 4‐pyridine aldehydes were metabolised by Mycobacterium tuberculosis BCG with the production of the corresponding acids and alcohols. The breakdown of isoniazid and the pyridine aldehydes was also observed in cell‐free extracts and some purification of the enzymes involved was achieved. It is suggested that there are two enzyme systems which metabolise isoniazid of which one may involve the intermediate formation of 4‐pyridine aldehyde.
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Jean Youatt (1962) studied this question.