Immunologic Incompetence of the Neoplastic Lymphocyte in Chronic Lymphocytic Leukemia

Article1 June 1966Immunologic Incompetence of the Neoplastic Lymphocyte in Chronic Lymphocytic LeukemiaJEROME I. BRODY, M.D., F.A.C.P., LAWRENCE H. BEIZER, M.D., F.A.C.P.JEROME I. BRODY, M.D., F.A.C.P.Search for more papers by this author, LAWRENCE H. BEIZER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1237 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this investigation was to evaluate the immune reactivity of the neoplastic lymphocyte in chronic lymphocytic leukemia by characterizing the response of patients with this blood dyscrasia to a polyvalent Salmonella antigen. The knowledge that 19S macroglobulin antibody (γM, IgM) is synthesized in part by the normal lymphocyte and represents a major initial defense against gram-negative septicemia (1, 2) and the failure of patients with lymphoproliferative disorders to successfully withstand such infections (3) implied that the leukemic lymphocyte may have lost an important biosynthetic function.There have been a number of difficulties associated with studying the dynamics of...References1. GITLINROSENMICHAEL DFJG: Transient 19S gamma-globulin deficiency in the newborn infant, and its significance. Pediatrics 31: 197, 1963. MedlineGoogle Scholar2. LA VIAFITCHGUNDERSONWISSLER MFFWCHRW: The relation of antibody formation to reticuloendothelial structure and function, in Reticuloendothelial Structure and Function, edited by HELLER, J. H. Ronald Press, New York, 1960. Google Scholar3. SHAWSZWEDBOGGSFAHEYFREIMORRISONUTZ RKCDRJCEEJP: Infection and immunity in chronic lymphocytic leukemia. Arch. Intern. Med. 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C.Requests for reprints should be addressed to Jerome I. Brody, M.D., Department of Medicine, Graduate Hospital of the University of Pennsylvania, Philadelphia, Pa. 19103. 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CLUFF, M.D., F.A.C.P., RICHARD C. REYNOLDS, M.D., F.A.C.P., DAVID L. PAGE, M.D., JOHN L. BRECKENRIDGE, M.D.NEONATAL LYMPHOCYTE REACTIVITY AS AN INDICATOR OF INTRAUTERINE BACTERIAL CONTACTStimulation der Blutlymphocyten durch Phytohämagglutinin bei chronischer Lymphadenose, Lymphosarkomatose und LymphogranulomatoseInability of Peripheral Blood Lymphocytes To React to A and B AntigensImmunologic Memory of the Normal and the Leukemic LymphocyteJEROME I. BRODY, M.D., F.A.C.P., FRANK OSKI, M.D.Immunological Aspects of Neoplasia 1 June 1966Volume 64, Issue 6Page: 1237-1245KeywordsAntigensChronic lymphocytic leukemiaHospital medicineImmune responseLymphocytesResearch grantsResearch laboratoriesSalmonellaSepsisTechnicians ePublished: 1 December 2008 Issue Published: 1 June 1966 PDF downloadLoading ...