Decreased Circulating T Cells During Viral Pharyngitis

Letters1 October 1974Decreased Circulating T Cells During Viral PharyngitisRICHARD J. MANGI, M.D., JOHN M. DWYER, M.D., PH.D., JAMES C. NIEDERMAN, M.D., FRED S. KANTOR, M.D.RICHARD J. MANGI, M.D.Search for more papers by this author, JOHN M. DWYER, M.D., PH.D.Search for more papers by this author, JAMES C. NIEDERMAN, M.D.Search for more papers by this author, FRED S. KANTOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-4-557_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: During the course of investigation of delayed hypersensitivity in cases of acute infectious mononucleosis, we have recently seen reversal of the normal peripheral blood T:B cell ratio in a controlled study of seven patients (Table 1) with presumed viral infections of the upper respiratory tract. These patients had pharyngitis, cervical adenopathy, and nonproductive coughfor less than 1 week. One patient (Patient 1) did develop pulmonary congestion and sputum production. Heterophil antibody was not present, and culture of the pharynx for B-hemolytic streptococci was negative in all patients. T cells were detected by formation of rosettes with...References1. WYBRAN J and FUDENBERG H: Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases. J Clin Invest 52: 1026-1032, 1973 CrossrefMedlineGoogle Scholar2. THORLEY J, SMITH J, and SANFORD J: B and T lymphocytes during systemic infection in humans (abstract). Clin Res 22: 455A, 1974 Google Scholar3. SHELDON P, PAPAMICHAIL M, and HEMSTED E: Thymic origin of atypical lymphoid cells in infectious mononucleosis. Lancet 2:1153-1155, 1973 CrossrefGoogle Scholar4. MUNYER T, DOLAN T, and MANGI R: Suppression of delayed hypersensitivity in MMR-vaccinated children and canine distemper virus-infected dogs (abstract). Clin Res 22:425A, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD J. MANGI, M.D.; JOHN M. DWYER, M.D., PH.D.; JAMES C. NIEDERMAN, M.D.; FRED S. KANTOR, M.D.Affiliations: Department of Medicine Yale University School of Medicine New Haven, Connecticut 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCellular immunity abnormalities in patients with recurrent Bell's palsyPeripheral Blood T and B Lymphocyte Subpopulations in Bell's PalsyDevelopment of serum and intestinal antibody response to rotavirus after naturally acquired rotavirus infection in manParticularity of Local Immunity in the Nasopharynx.SEVERE DISSEMINATED ADENOVIRUS INFECTION SUCCESSFULLY TREATED WITH A THYMIC HUMORAL FACTOR, THFLymphocyte populations in acute viral gastroenteritisInfluenza: Response of T-Cell Lymphopenia to ThymosinReversible enteritis and lymphopenia in infantile X-linked agammaglobulinemiaLymphocyte Changes in Viral InfectionsPETER D. UTSINGER, M.D. 1 October 1974Volume 81, Issue 4Page: 557-558KeywordsBlood cellsHypersensitivityPharyngitisPharynxRespiratory systemSputumT cellsUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 October 1974 PDF downloadLoading ...