Why the study?
Does histone infusion cause dose-dependent left and right ventricular dysfunction in a mouse model?
Does histone infusion cause dose-dependent left and right ventricular dysfunction in a mouse model?
Circulating histones cause dose-dependent differential effects on left and right ventricular function, providing a potential therapeutic target for cardiac dysfunction in critical illness.
Histone effects on biventricular function merit exploration as a therapeutic target in critical illness; hypothesis-generating in this animal model.
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Alhamdi et al. (2015) studied this question.
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