Editorial: Myocardial Remodeling: Mechanisms and Translational Implications

Left ventricular remodeling remains the major determinant of cardiac function and survival after recovery from acute myocardial infarction (AMI) Different available and promising therapeutic approaches are available to treat and attenuate the adverse effects of cardiac remodeling process by targeting the underlying pathophysiological mechanisms. Mainly, the RAAS regulates post-AMI cardiac remodeling process As a consequence, blocking RAAS acts in a manner to stop left ventricular remodeling, reduce mortality and improve short-and long-term survival (Pfeffer et al., 1990). The goal of this Research Topic was to understand how aberrant cardiac remodeling contributes to the development and progression of heart failure (HF) and how to exploit this knowledge for therapeutic benefits to improve cardiac function and to prevent HF progression. In this Research Topic we have eight original research articles and one review article summarizing the recent advances in myocardial remodeling.