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April 1, 1981Biochemistry

Polymerization of myosin from smooth muscle of the calf aorta

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Population

Myosin from smooth muscle of the calf aorta and rabbit skeletal muscle myosin

Comparison

Dialysis at low ionic strength, varying ionic… vs Rabbit skeletal muscle myosin

Design

Preclinical

Authors

JMJoseph MegermanBoston Scientific (United States)SLSusan LoweyUniversity of Vermont

Discussion

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Implication

Does not yet inform clinical vascular management; extends biochemical models of smooth muscle myosin assembly.

Structured PICO

P
Population
Myosin from smooth muscle of the calf aorta and rabbit skeletal muscle myosin
I
Intervention
Dialysis at low ionic strength, varying ionic strength, pH, and hydrostatic pressure
C
Comparator
Rabbit skeletal muscle myosin
O
Outcome
Polymerization behavior and self-association reactionssurrogate

Smooth muscle myosin from calf aorta exhibits more complex polymerization behavior compared to skeletal muscle myosin, which may relate to differences in assembly modes.

Cite This Study

Megerman et al. (1981) studied this question.

synapsesocial.com/papers/6a86a43cbf8a68ea2b6ed97fhttps://doi.org/10.1021/bi00511a006
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Filaments from Purified Smooth Muscle Myosin1973 · 18 citations
  2. 2Assembly of smooth muscle myosin into side-polar filaments.1977 · 155 citations
  3. 3Stability of myosin filaments1968 · 140 citations
  4. 4DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION1949 · 16,212 citations