Conformation confirmation: The nine conformers of the neurotransmitter γ-aminobutyric acid (GABA) identified in the gas phase can serve as a basis to represent the shape of GABA. An n→π* interaction guided by the Bürgi–Dunitz trajectory of nucleophilic addition is thought to be relevant in the stabilization of two of the folded conformers (gG1 and gG3 in the picture).
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Blanco et al. (2010) studied this question.
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