Why the study?
Antithrombotic medication is recommended for specific cardiovascular indications, but antithrombotic use, treatments prescribed, and associated complications needed characterization in older adults living with dementia.
Antithrombotic use and polypharmacy are highly prevalent among hospitalized older adults with dementia but decrease post-discharge, highlighting the need for shared decision-making to balance risks and benefits.
High antithrombotic use persists post-discharge in dementia patients; leaves open questions on appropriateness and net benefit.
Antithrombotic medication is recommended for individuals who have a history of atrial fibrillation, venous thromboembolism, acute coronary events, or post-percutaneous coronary intervention. The purpose of this study was to describe the use of antithrombotics among older adults living with dementia at hospital admission and 1-month follow-up, treatments prescribed, and associated complications. The sample included 404 hospitalized older adults living with dementia, the majority of whom were White females, mean age in years of 82 (SD = 8). On admission, 69% of the patients were on at least one antithrombotic medication, and at 1-month post-discharge, this decreased to 64%. At 1-month post-discharge, the percentage of individuals on two or more antithrombotics decreased from admission at 34% to 14%. On admission, 11 (4%) of patients were admitted with adverse events from antithrombotics, and at 1-month post-discharge 5 (2%), patients were readmitted due to adverse events from antithrombotics. Given the risks and benefits of antithrombotic use among older adults living with dementia, a shared decision-making approach with patients and caregivers is recommended. This approach is the best way to help patients achieve their individual goals of care.
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Resnick et al. (2025) studied this question.
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