UNLABELLED: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial and heterogeneous disorder, highly prevalent in children and characterized by three main components: inattention, lack of inhibitory control and hyperactivity. Epidemiological evidence reveals that ADHD is associated with nicotine exposure, mostly, with prenatal cigarette smoking. Mice deleted for the beta2-subunit gene of the neuronal nicotinic receptor are proposed as a simple and reliable animal model for ADHD. CONCLUSION: Nicotinic agonists targeting the alpha4beta2 nicotinic receptors alleviate ADHD symptoms and may possibly contribute to an efficient therapy of ADHD children.
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Granon et al. (2006) studied this question.
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