Racemic 6,6′-dimethylbiphenyl-2,2′-dicarboxylic acid (1) could be conveniently synthesized and efficiently resolved by the recrystallization of the brucine salts in satisfactory yields. Each enantiomer, thus obtained, was confirmed to be optically pure from a high-performance liquid chromatographic (HPLC) analysis on an optically active column.
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Kanoh et al. (1987) studied this question.
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