June 1, 1990Journal of Clinical InvestigationOpen Access

A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat.

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Population

Munich-Wistar rats

Comparison

Arterial denudation of the left main renal… vs Right kidney or non-denuded kidneys

Design

Preclinical

Authors

VKValentina KonCross-Cutting Cardiology RHRobert C. HarrisChildren's Medical Center IIIekuni IchikawaShinshu University

Discussion

Member takes

Implication

Renal artery endothelium may regulate intrarenal hemodynamics in animal models; hypothesis-generating and leaves open human translation.

Structured PICO

Population

Munich-Wistar rats

Intervention

Arterial denudation of the left main renal artery followed by infusion of vasodilators (acetylcholine, atrial natriuretic peptide, nitroprusside, or histamine)

Comparator

Right kidney (intact endothelium) or non-denuded kidneys

Outcome

Renal plasma flow rate (RPF) and glomerular filtration rate (GFR)surrogate

The main renal artery endothelium plays a major regulatory role in downstream intrarenal hemodynamics and vascular resistance through the release of endothelium-derived relaxing factor.

Cite This Study

Kon et al. (1990) studied this question.

synapsesocial.com/papers/6a86adf6a6ddb97d43d3b334 https://doi.org/10.1172/jci114628

View Full Paper

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Bookmark

A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider