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A simple method to covalently crosslink chitosan using poly(ethylene glycol) diacid as crosslinking agent is proposed. Networks net -chitosan -ι- PEG(COOH) 2 were obtained by heating chitosan in aqueous PEG 600 (COOH) 2 solutions at a temperature higher than 60°C. IR spectroscopy revealed the formation of amide bonds. It is shown that the obtained chemical networks are pH-sensitive hydrogels with enhanced hydrophilicity. The equilibrium degree of swelling of the hydrogels is determined by the conditions of their preparation - heating temperature and mole ratio between chitosan and the crosslinker. The ability of the polymer networks to facilitate bone regeneration processes was shown by in vivo implantation experiments.
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Mincheva et al. (2004) studied this question.
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