The effect of experimental leukopenia induced by nitrogen mustard on chronic gingival inflammation has been studied in dogs. The effect on the gingivae was assessed by measurements of crevicular leukocytes, gingival fluid and the level of acid phosphatasc activity in samples from gingival crevices. During leukopenia a reduction in all these parameters was observed. The values returned to normal in the post‐leukopenic period. The results obtained indicate that crevicular leukocytes may contribute to the enzyme milieu in the gingival crevice and that these cells, through their lysosomal enzymes, may influence the tendency of the dento‐gingival vessels to show increased permeability.
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Attström et al. (1971) studied this question.
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